Early brainstem [18F]THK5351 uptake is linked to cortical hyperexcitability in healthy aging

BACKGROUND. Neuronal hyperexcitability characterizes the early stages of Alzheimer’s disease (AD). In animals, misfolded tau and amyloid-β (Aβ) protein accumulation — both central to AD neuropathology promote cortical excitability neuronal network dysfunction. healthy humans, Aβ aggregates are first detected, respectively, in brainstem frontomedial temporobasal cortices, decades prior onset cognitive symptoms. Whether is related its associated neuroinflammation aggregations remains unknown.